REVIEW article
Front. Immunol.
Sec. Microbial Immunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1584001
Interacting roles of gut microbiota and T cells in the development of autoimmune hepatitis
Provisionally accepted
- 1Nanjing Medical University, Nanjing, China
- 2Nanjing First Hospital, Nanjing, Liaoning Province, China
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Autoimmune hepatitis (AIH) is a progressive liver inflammatory disease mediated by an autoimmune response, with an increasing incidence rate. In severe cases, AIH will rapidly progress to liver cirrhosis and liver failure and even lead to death. The gut microbiota is a complex ecosystem that significantly regulates physiological and pathological processes among various digestive system diseases. It is widely acknowledged that there is a critical correlation between AIH and the gut microbiota.Numerous studies have demonstrated that the composition of gut microbiota in individuals with AIH differs markedly from that of healthy subjects. Immune cells, especially T cells, are pivotal in the development of AIH, closely interacting with the gut microbiota. In this review, we discuss the regulatory role of the gut microbiota in T cell-mediated development of AIH, as well as the effect of T cells on the composition of the gut microbiota in AIH. By modulating gut microbiota or immunity pathways, novel opportunities are provided to regulate the balance of the immune-microbial microenvironment, targeting the dual factor for autoimmune hepatitis therapies.
Keywords: Gut Microbiota, Autoimmune Hepatitis, T cells, Interaction, immune microenvironment
Received: 26 Feb 2025; Accepted: 29 Apr 2025.
Copyright: © 2025 Wu, Ge, Lv and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Chengyu Lv, Nanjing First Hospital, Nanjing, Liaoning Province, China
Qifeng He, Nanjing First Hospital, Nanjing, Liaoning Province, China
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