ORIGINAL RESEARCH article

Front. Immunol.

Sec. Comparative Immunology

Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1584092

Inactivated Rothia nasimurium promotes a persistent antiviral immune status in porcine alveolar macrophages

Provisionally accepted
Aida Tort MiroAida Tort Miro1Uxia AlonsoUxia Alonso2Beatriz Martín-MurBeatriz Martín-Mur3Jordana Muñoz-BasagoitiJordana Muñoz-Basagoiti1Yan ZengYan Zeng4David Marín-MoraledaDavid Marín-Moraleda1Enrique EzcurraEnrique Ezcurra1Sergio Roberto Montaner TarbesSergio Roberto Montaner Tarbes1Maria Jesús NavasMaria Jesús Navas1Marta MuñozMarta Muñoz1Paula MonleónPaula Monleón1Esmeralda CanoEsmeralda Cano1Carles Vilalta SansCarles Vilalta Sans1Marc CaballéMarc Caballé5Lourdes CriadoLourdes Criado5Karl KochanowskiKarl Kochanowski1Francesc AccensiFrancesc Accensi6Virginia AragónVirginia Aragón1Florencia Correa-FizFlorencia Correa-Fiz1Anna Esteve-CodinaAnna Esteve-Codina3Fernando RodriguezFernando Rodriguez1*Jordi ArgilaguetJordi Argilaguet1*
  • 1IRTA-CReSA, Centre for Research on Animal Health, Bellaterra, Spain
  • 2Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan
  • 3Centro Nacional de Análisis Genómico (CNAG), Barcelona, Spain
  • 4College of Veterinary Medicine, Jilin Agriculture University, chang chun, China
  • 5Institute of Agrifood Research and Technology (IRTA), Barcelona, Catalonia, Spain
  • 6Autonomous University of Barcelona, Barcelona, Catalonia, Spain

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Globalization has increased the incidence of infectious diseases in livestock, further aggravated by the reduction of antibiotic usage. To minimize the resulting economic consequences to the meat production industry, as well as the risk of zoonotic events, the use of immunostimulants has emerged as a potential strategy to enhance animal resilience to diseases. In particular, the capability of bacterial-based immunostimulants to modulate innate immune cells functionality makes them cost-effective candidates as vaccine adjuvants, antimicrobials, or preventive immunostimulators inducing long-term innate immune memory in livestock. However, further research is required to identify novel bacterial strains Deleted: 3 39 Deleted: 4, 40

Keywords: Rothia nasimurium, Immunostimulant, adjuvants, antivirals, Innate immune memory, porcine alveolar macrophages HI-Ro

Received: 26 Feb 2025; Accepted: 05 May 2025.

Copyright: © 2025 Tort Miro, Alonso, Martín-Mur, Muñoz-Basagoiti, Zeng, Marín-Moraleda, Ezcurra, Montaner Tarbes, Navas, Muñoz, Monleón, Cano, Vilalta Sans, Caballé, Criado, Kochanowski, Accensi, Aragón, Correa-Fiz, Esteve-Codina, Rodriguez and Argilaguet. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Fernando Rodriguez, IRTA-CReSA, Centre for Research on Animal Health, Bellaterra, Spain
Jordi Argilaguet, IRTA-CReSA, Centre for Research on Animal Health, Bellaterra, Spain

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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