CASE REPORT article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1586663
This article is part of the Research TopicCase Reports in Autoimmune and Autoinflammatory Disorders: Volume IIView all 20 articles
Efgartigimod in the treatment of Guillain-Barré syndrome: case series
Provisionally accepted
- 1Renmin Hospital of Wuhan University, Wuhan, China
- 2Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, Hubei Province, China
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Guillain-Barré syndrome (GBS) is a rare neurological disorder characterized by muscle weakness and paralysis. Although the exact etiology remains unclear, the current standard treatments include intravenous immunoglobulin (IVIG) and plasma exchange (PLEX) therapy. While the majority of GBS patients respond well to immunotherapy, some severe cases can be fatal. Efgartigimod, an Fc receptor antagonist, has been utilized in the treatment of various autoimmune diseases. However, its clinical efficacy in acute GBS has been rarely documented. In this study, we administered intravenous efgartigimod to four patients with different subtypes of acute GBS, two of whom received efgartigimod monotherapy without concomitant glucocorticoids, IVIG, or PLEX. The treatment outcomes were favorable, suggesting that intravenous efgartigimod may represent a promising therapeutic option for acute GBS. Further research is warranted to validate these preliminary findings.
Keywords: Guillain-Barré syndrome, efgartigimod, Miller-Fisher syndrome, Acute motor and sensory axonal neuropathy, Acute inflammatory demyelinating polyneuropathy
Received: 05 Mar 2025; Accepted: 25 Aug 2025.
Copyright: © 2025 Deng, Kong, Wang, Wang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xufeng Wang, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, 430061, Hubei Province, China
Tao Li, Renmin Hospital of Wuhan University, Wuhan, China
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