ORIGINAL RESEARCH article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1586784
The value of nucleoporin 188 in diagnosis, prognosis and immunoregulation: from pan-cancer analysis to gastric cancer verification
Provisionally accepted
- 1Jianhu People’s Hospital, Yancheng Shi, China
- 2Jiangsu Health Vocational College, Nanjing, China
- 3Suzhou Vocational Health College, Suzhou, Jiangsu Province, China
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Background: Nucleoporin 188 (NUP188) is a vital component of the nuclear pore complex that regulates cancer progression, but its role in diagnosis, prognosis, and immunoregulation in pan-cancer remains unclear.Methods: A comprehensive exploration of the value of NUP188 was performed using different platforms and software, including TCGA, HPA, UALCAN, TISIDB, cBioPortal, STRING, GSCALite, cancerSEA databases, and R software. The expression of NUP188 in gastric cancer (GC) was detected by immunohistochemistry. The association between NUP188 and clinicopathologic features was explored, and the predictive value of NUP188 was determined. The effect of NUP188 knockdown on the proliferation, migration, and invasion of GC cells was detected in vitro and vivo.Results: NUP188 was dysregulated in most human cancers compared to normal tissues with great diagnostic accuracy. The NUP188 expression was associated with molecular subtype, pathologic stage, prognosis, cancer status, and genomic heterogeneity in multiple cancer types. NUP188 was also related to the immune subtype and infiltrating levels of immune cells. The protein level of NUP188 was both upregulated in GC tissues, and was related to HP infection, depth of invasion, distant metastasis, TNM stage, and overall survival of GC patients. NUP188 interference restrained the proliferation, migration, and invasion of GC cells, and inhibited the GC growth in vivo.Conclusion: NUP188 plays a potential role in pan-cancer diagnosis and prognosis and may serve as a novel biomarker for tumor immunotherapy.
Keywords: Nucleoporin 188, diagnosis, prognosis, Immunoregulation, Pan-cancer, gastric cancer
Received: 03 Mar 2025; Accepted: 23 Jul 2025.
Copyright: © 2025 Zhu, Peng and Cai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Huanhuan Cai, Suzhou Vocational Health College, Suzhou, Jiangsu Province, China
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