REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1586959
This article is part of the Research TopicCancer Immunity and Metabolic Reprogramming: Pioneering Precision ImmunotherapiesView all articles
Reprogramming of glucose metabolism in pancreatic cancer: mechanisms, implications, and therapeutic perspectives
Provisionally accepted
- 1The Second Clinical Medical School, Lanzhou University, Lanzhou, China
- 2The Second Hospital of Lanzhou University & The Second Clinical Medical School, Lanzhou University, Lanzhou, China
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As a typical pathological feature of pancreatic ductal adenocarcinoma, reprogramming of glucose metabolism synergistically drives the tumorigenesis and development process through molecular mechanisms such as regulating the expression of driver genes, modifying key functional proteins, triggering mitochondrial metabolism abnormality, and remodeling the tumor microenvironment. It is worth noting that this metabolic remodeling phenomenon is significantly associated with the formation of chemoresistance. Based on the latest research progress, this paper systematically describes the molecular basis of glucose metabolic reprogramming in pancreatic cancer, drug resistance characteristics and its targeted intervention strategies, and provides a theoretical framework for the research and development of innovative drugs.
Keywords: Pancreatic Cancer, glucose metabolism, Tumor Microenvironment, treatment resistance, therapeutic strategy
Received: 03 Mar 2025; Accepted: 11 Jun 2025.
Copyright: © 2025 Zhang, Li, Niu, Fan, Li and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xin Li, The Second Hospital of Lanzhou University & The Second Clinical Medical School, Lanzhou University, Lanzhou, China
Hui Zhang, The Second Hospital of Lanzhou University & The Second Clinical Medical School, Lanzhou University, Lanzhou, China
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