ORIGINAL RESEARCH article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1588287
This article is part of the Research TopicNovel Biomarkers for Early Diagnosis, involved in Autoimmune and Autoinflammatory DiseasesView all 13 articles
The Diagnostic and Prognostic Role of novel biomarkers in Anti-neutrophil cytoplasmic antibody (ANCA)-Associated Vasculitis
Provisionally accepted
- International Hospital, Peking University, Beijing, China
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Background: ANCA-associated vasculitis (AAV) is a group of autoimmune diseases characterized by small vessel inflammation, diagnosed primarily through clinical features, histopathology, and ANCA testing. Novel biomarkers derived from routine blood counts, such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-tolymphocyte ratio (MLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI), may support disease assessment. This study evaluated their utility in distinguishing AAV patients, reflecting disease activity, and predicting prognosis.: In this retrospective case-control study, 65 AAV patients and 65 age-and sexmatched healthy controls were enrolled. AAV diagnosis adhered to the 2012 Chapel Hill Consensus and the American College of Rheumatology 1990 criteria. NLR, PLR, MLR, SII, and SIRI were calculated from complete blood counts. Disease activity (Birmingham Vasculitis Activity Score, BVAS), extent (Disease Extent Index, DEI), damage (Vasculitis Damage Index, VDI), and prognosis (Five-Factor Score, FFS 2009) were assessed. Statistical analyses included Mann-Whitney U tests, Spearman correlations, and receiver operating characteristic (ROC) curves to evaluate discriminatory and predictive capacities.Results: AAV patients exhibited significantly higher NLR (6.
Keywords: Monocyte-to-lymphocyte ratio, systemic immune-inflammation index, systemic inflammation response index, disease activity, prognosis
Received: 05 Mar 2025; Accepted: 27 May 2025.
Copyright: © 2025 Yu, Zhang, Zhang, Long, Li, Zou, Wang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Sheng-Guang Li, International Hospital, Peking University, Beijing, China
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