ORIGINAL RESEARCH article
Front. Immunol.
Sec. Mucosal Immunity
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1589421
Remarkable Increase in Interleukin-5 Receptor Expression beyond Tissue Eosinophils in Inflammatory Bowel Disease
Provisionally accepted
- 1College of Medicine, Seoul National University, Seoul, Seoul, Republic of Korea
- 2Department of Pediatrics, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea
- 3Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi, Republic of Korea
- 4Department of Pediatrics, Seoul National University Bundang Hospital, Seoul, Republic of Korea
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The role of tissue eosinophils and their relationship with interleukin-5 in gastrointestinal disorders have not been elucidated. This study aimed to analyze tissue eosinophils and interleukin-5 receptor-α subunit (IL-5RA) expression on eosinophils in inflammatory bowel disease (IBD). Methods: Blood and stool test results and radiologic and endoscopic findings in pediatric patients, who were newly diagnosed with IBD, eosinophilic gastrointestinal diseases (EGIDs), or disorders of gut-brain interactions were retrospectively reviewed. Tissue eosinophil counts were analyzed, and immunohistochemistry was performed using an antibody against IL-5RA expressed on eosinophils in the colonic mucosa. Results: The tissue eosinophil count and IL-5RAexpressing eosinophil density were significantly different among the three groups (P<0.005). IL-5RA expression was significantly higher in the IBD group than in the EGID group (P<0.001). In IBD, tissue IL-5RA expression was positively correlated with platelet count, erythrocyte sedimentation rate, and highly sensitive C-reactive protein, and negatively correlated with hemoglobin and albumin. In Crohn's disease (CD), higher IL-5RA expressions were observed with higher pediatric CD activity index (P<0.005). The optimal cut-off value for IL-5RA-expressing eosinophil density was 69.4/high- power field. Discussion: The expression of IL-5RA in tissue eosinophils is elevated in treatment naïve IBD. IL-5RA expression may reflect disease severity and its extent of involvement in early active CD.
Keywords: eosinophil, Interleukin-5 receptor, inflammatory bowel disease, Pathogenesis, Proinflammatory cytokine
Received: 07 Mar 2025; Accepted: 28 Apr 2025.
Copyright: © 2025 Kim, Oh and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hye Ran Yang, College of Medicine, Seoul National University, Seoul, 03080, Seoul, Republic of Korea
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