Nan Zhang1†
Haiyang Wu- 1Department of Tumor Ward, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- 2Department of Operating Room, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China
- 3Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- 4Department of Orthopaedics, Baodi Hospital Affiliated to Tianjin Medical University, Tianjin, China
A Commentary on
Bibliometric analysis of targeted immunotherapy for osteosarcoma-current knowledge, hotspots and future perspectives
by Hu Y, Yang R, Ni S and Song Z (2025) Front. Immunol. 15:1485053. doi: 10.3389/fimmu.2024.1485053
Bibliometrics, a sub-discipline of library and information science, employs mathematical and statistical methods to quantify various characteristics of documents, thereby describing, evaluating, and forecasting the current state and future trends of scientific and technological progress (1, 2). In recent years, the exponential growth in biomedical literature has garnered significant attention for bibliometrics as a method capable of quantitatively and qualitatively analyzing research trends and hotspots within a given discipline. Take osteosarcoma as an example, our preliminary statistics indicate that there have already published over 14 bibliometric articles related to osteosarcoma (3–7). However, it is noteworthy that despite the increasing number of these articles, there is substantial variability in their research methodologies, impacting the comparability and rigor of the results (3–7).
Furthermore, unlike meta-analyses and other clinical studies that are guided by established protocols or checklists, bibliometrics lacks a definitive international guideline (8, 9). This absence creates challenges for researchers in selecting methodologies, processing data, and interpreting results. In this context, we aim to examine the current issues in bibliometrics, using a recently accepted article by the Frontiers in Immunology as a case study. We also call for multidisciplinary collaboration to develop a universally accepted bibliometric guideline, enhancing the consistency and reliability of research.
We read with great interest on the publication by Hu et al. (10) titled “Bibliometric analysis of targeted immunotherapy for osteosarcoma-current knowledge, hotspots and future perspectives”, which has published in the issue of Frontiers in Immunology. By using bibliometrics, it highlights the global trends in the application of targeted immunotherapy in the field of osteosarcoma, and offers insights into current challenges and future directions in this area. Overall, this study reported the annual publications, main contributors including countries/regions, institutions and authors, core journals and references, as well as popular keywords and their change trend in this domain. As the authors state, tumor immunotherapy research has become a high-profile area of osteosarcoma, the importance of this study deserves to be recognized. However, in terms of the paper retrieval and software analysis process, we would like to discuss with authors as follows:
Firstly, we agree with the authors’ use of Web of Science Core Collection (WOSCC) database for data retrieval. Most previous studies have considered WOSCC to be one of the most suitable databases for bibliometric analysis (11, 12). However, to the best of our knowledge, WOSCC is a comprehensive citation indexing database comprising multiple sub-databases including SCI-EXPANDED, SSCI, Arts & Humanities Citation Index (AHCI), Conference Proceedings Citation Index - Science (CPCI-S), Conference Proceedings Citation Index - Social Science & Humanities (CPCI-SSH), and so on. In our opinion, the inclusion of all these sub-databases for sourcing eligible articles might not align optimally. Of them, SCI-EXPANDED emerges as the potential optimal choice for conducting bibliometric analyses. And in most previous bibliometric studies, many authors chose the data form SCI-EXPANDED as their data source. Consistent with this view, several scholars also believe that it is inappropriate to combine the use of these different types of databases in one bibliometric analysis (13, 14). However, in this study, the authors did not further explain the use of the WOSCC sub-databases. If all sub-databases were used, the necessity worth further discussion.
Secondly, in this study, the author use “TS” as the field tags. According to WOSCC, TS refers to topic search that comprises the title (TI), abstract (AB), author keywords (AK), and keyword plus (KP) terms. As for keywords, AK means keywords are provided by the authors, while KP are those automatically extracted by the system. In our experience, KP might not be appropriate to include in the search process. Although TS could expand the scope of literature search, many unrelated literatures in this field will also be included. For example, when we use the search terms of Hu’s study (10) and the field tags including TI, AK, and AB to search for literature, only 465 relevant articles were obtained from 2000 to 2023. Moreover, after we checked the literature abstracts and contents in Table 1 of Hu’s study (10), which has summarized the top 10 core literatures in the field of targeted immunotherapy for osteosarcoma, at least five (50%) of the articles do not correspond to the research topic (15–19). Such a high proportion of unrelated literature not only distorts citation analysis and co-citation networks but also undermines the validity of subsequent bibliometric mapping and clustering analyses. The inclusion of irrelevant articles can artificially inflate certain research areas, create false thematic connections, and ultimately lead to misleading conclusions about the intellectual structure and research trends in the field. Therefore, while TS searches may appear comprehensive, their tendency to capture unrelated literature poses a significant threat to the accuracy and reliability of bibliometric studies.
In addition, search terms are also very important because some medical terms represent the same thing although they have different forms. In this study, the author only used the term of “immunotherapy” to find immunotherapy-related datasets. We believe this term could not totally identified all related studies and many potentially relevant papers may be missed. In our opinion, the author also should add the following terms into the search formula including “immune checkpoint blockade*”, “immune checkpoint inhibitors *”, “CTLA-4”, “PD-L1”, “PD-1” and so on. Moreover, as many terms have plural and singular alternation. The author could use several wildcards such as “*”. The wildcard “*” means it could in place of any number of characters. For example, “immunotherap*” would also return the terms of “immunotherapy” and “immunotherapies” (Table 1).
Table 1. Recommended Protocols for Bibliometric Analysis in Medical Research.
Last but not least, according to our knowledge, HisCite, CiteSpace and VOSviewer are all the most popular tools used to visualize scientific literature. The parameter settings significantly impact their outcomes. Choosing specific words or terms and assigning weights directly influences the study’s findings. Optimal keyword selection better captures the literature’s themes, directly impacting result accuracy and interpretability. Thus, it is crucial to sensibly select and adjust parameters when using HisCite, CiteSpace and VOSviewer for bibliometric analysis, considering research objectives and data characteristics. However, the authors did not explain the detailed parameter settings for HisCite, CiteSpace and VOSviewer in this study, hindering subsequent researchers from validating these outcomes.
First, node selection criteria constitute a primary factor influencing the visualization. For instance, in CiteSpace, the selection of node types (authors, institutions, keywords, cited references) and the threshold for the number of nodes per time slice (Top N or Top N%) directly alter the elements included in the network. Excessively high thresholds may omit emerging or potentially significant research entities, whereas overly low thresholds may introduce excessive noise, resulting in overly complex maps that obscure core structures. Similarly, in VOSviewer, the minimum occurrence threshold for entities such as keywords or authors (minimum number of occurrences of a keyword/author) serves to filter core elements while excluding low-frequency noise. Second, the configuration of time slicing and time span is critical for dynamic evolution analysis. A distinctive feature of CiteSpace lies in its time-zone and timeline views, which reveal the trajectory of knowledge development. The duration of time slices (years per slice) affects the sensitivity of burst detection and the stability of cluster labels. Excessively short time slices may fragment evolutionary trends, whereas overly long slices may obscure short-term significant changes. Many studies employing these tools mention the software versions and basic data sources but often lack detailed justification for specific parameter settings, such as the rationale for threshold selection or pruning methods. Such omissions not only compromise the reproducibility of findings but also hinder readers’ ability to evaluate the robustness of the analytical results.
Given the current landscape, we posit that the formulation of an international bibliometric guideline is of paramount importance. Such a guideline should encompass methodologies for the acquisition and processing of bibliometric data, definitions and applications of standard bibliometric indicators, and protocols for data analysis and interpretation. Moreover, the development of this guideline necessitates the collaboration and engagement of researchers from diverse disciplines, including library and information science, statistics, computer science, and medicine. These experts must collectively deliberate and address the pivotal issues inherent in bibliometric research. To advance this objective, we propose initiating discussions and calls for action on the formulation of bibliometric guidelines at international academic conferences and in scholarly journals. This initiative should invite the participation and insights of experts and scholars from pertinent fields. Furthermore, the establishment of an International Bibliometrics Research Consortium could significantly enhance collaboration and communication among researchers worldwide. This consortium would facilitate the sharing of research experiences and methodologies, thereby fostering the advancement of bibliometric science.
In summary, we congratulate the authors and colleagues for their exceptional comprehensive bibliometric study, providing a detailed analysis of research trends and key contributors in the field of targeted immunotherapy for osteosarcoma. Nevertheless, we believe that our suggestions regarding the search process and software parameter settings could assist the authors in obtaining more reliable analytical outcomes, thereby avoiding biases that might misguide scholars in this field. Additionally, bibliometric analysis has become an increasingly important and recognized methodology; however, there is still a lack of guidelines, akin to reviews or meta-analyses, to guide scholars in conducting proper data retrieval, analysis, and interpretation. Therefore, we advocate for increased collaboration among scholars to develop guidelines or expert consensus for the use of bibliometric analysis at the earliest opportunity.
Author contributions
NZ: Writing – original draft. WL: Writing – original draft. HW: Writing – review & editing. QG: Writing – review & editing.
Funding
The author(s) declare that no financial support was received for the research and/or publication of this article.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Generative AI statement
The author(s) declare that no Generative AI was used in the creation of this manuscript.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
References
1. Cheng K, Guo Q, Shen Z, Yang W, Wang Y, Sun Z, et al. Bibliometric analysis of global research on cancer photodynamic therapy: focus on nano-related research. Front Pharmacol. (2022) 13:927219. doi: 10.3389/fphar.2022.927219
2. Wu H, Cheng K, Guo Q, Yang W, Tong L, Wang Y, et al. Mapping knowledge structure and themes trends of osteoporosis in rheumatoid arthritis: A bibliometric analysis. Front Med (Lausanne). (2021) 8:787228. doi: 10.3389/fmed.2021.787228
3. Shen Y, Shao X, Chen J, and Tang X. A 10-year bibliometric analysis in the field of osteosarcoma treatment from 2014 to 2023. Discov Oncol. (2025) 16:255. doi: 10.1007/s12672-025-02007-2
4. Shang J, Zhao F, Xie L, Wang Y, Li B, and Jin C. Trends and future directions of autophagy in osteosarcoma: A bibliometric analysis. Open Med (Wars). (2024) 19:20241080. doi: 10.1515/med-2024-1080
5. Tu JB, Liu T, Li JF, Long J, Wang X, Liu WC, et al. Global research trends and hotspots in metabolomics of osteosarcoma: a decade-spanning bibliometric and visualized analysis. Front Immunol. (2024) 15:1463078. doi: 10.3389/fimmu.2024.1463078
6. Wang X, Cao X, Dai Z, and Dai Z. Bibliometric analysis and visualisation of research hotspots and frontiers on omics in osteosarcoma. J Cancer Res Clin Oncol. (2024) 150:393. doi: 10.1007/s00432-024-05898-w
7. Pei Y, Guo Y, Wang W, Wang B, Zeng F, Shi Q, et al. Extracellular vesicles as a new frontier of diagnostic biomarkers in osteosarcoma diseases: a bibliometric and visualized study. Front Oncol. (2024) 14:1359807. doi: 10.3389/fonc.2024.1359807
8. Freemantle N and Irs A. Will the ROB-ME checklist prevent omission bias in meta-analyses? BMJ. (2023) 383:2653. doi: 10.1136/bmj.p2653
9. Fernández-Castilla B, Said-Metwaly S, Kreitchmann RS, and Van Den Noortgate W. What do meta-analysts need in primary studies? Guidelines and the SEMI checklist for facilitating cumulative knowledge. Behav Res Methods. (2024) 4:3315–29. doi: 10.3758/s13428-024-02373-9
10. Hu Y, Yang R, Ni S, and Song Z. Bibliometric analysis of targeted immunotherapy for osteosarcoma-current knowledge, hotspots and future perspectives. Front Immunol. (2025) 15:1485053. doi: 10.3389/fimmu.2024.1485053
11. Wu H, Wang Y, Tong L, Yan H, and Sun Z. The global research trends and hotspots on developmental dysplasia of the hip: A bibliometric and visualized study. Front Surg. (2021) 8:671403. doi: 10.3389/fsurg.2021.671403
12. Wu H, Sun Z, Tong L, Wang Y, Yan H, and Sun Z. Bibliometric analysis of global research trends on male osteoporosis: a neglected field deserves more attention. Arch Osteoporos. (2021) 1:154. doi: 10.1007/s11657-021-01016-2
13. Ho YS. Comment on: Trends in research related to high myopia from 2010 to 2019: a bibliometric and knowledge mapping analysis. Int J Ophthalmol. (2022) 1:178–9. doi: 10.18240/ijo.2022.01.28
14. Ho YS. Comments on: ‘Glyphosate and its toxicology: A scientometric review’, Sci. Total Environ. (2020) 733:139359. doi: 10.1016/j.scitotenv.2020.139359
15. Ahmed N, Brawley VS, Hegde M, Robertson C, Ghazi A, Gerken C, et al. Human epidermal growth factor receptor 2 (HER2) -specific chimeric antigen receptor-modified T cells for the immunotherapy of HER2-positive sarcoma. J Clin Oncol. (2015) 33:1688–96. doi: 10.1200/JCO.2014.58.0225
16. Majzner RG, Theruvath JL, Nellan A, Heitzeneder S, Cui Y, Mount CW, et al. CAR T cells targeting B7-H3, a pan-cancer antigen, demonstrate potent preclinical activity against pediatric solid tumors and brain tumors. Clin Cancer Res. (2019) 25:2560–74. doi: 10.1158/1078-0432.CCR-18-0432
17. Nakatsuka S, Oji Y, Horiuchi T, Kanda T, Kitagawa M, Takeuchi T, et al. Immunohistochemical detection of WT1 protein in a variety of cancer cells. Mod Pathol. (2006) 19:804–14. doi: 10.1038/modpathol.3800588
18. Lu YC, Parker LL, Lu T, Zheng Z, Toomey MA, White DE, et al. Treatment of patients with metastatic cancer using a major histocompatibility complex class II-restricted T-cell receptor targeting the cancer germline antigen MAGE-A3. J Clin Oncol. (2017) 35:3322–9. doi: 10.1200/JCO.2017.74.5463
Keywords: osteosarcoma, immune function, immunotherapy, immune checkpoint inhibitor, targeted therapy
Citation: Zhang N, Li W, Wu H and Guo Q (2025) Commentary: Bibliometric analysis of targeted immunotherapy for osteosarcoma-current knowledge, hotspots and future perspectives. Front. Immunol. 16:1590342. doi: 10.3389/fimmu.2025.1590342
Received: 09 March 2025; Accepted: 27 June 2025;
Published: 16 July 2025.
Edited by:
Debasish Bandyopadhyay, The University of Texas Rio Grande Valley, United StatesReviewed by:
Marcos Edgar Herkenhoff, Santa Catarina State University, BrazilWencai Liu, Shanghai Jiao Tong University, China
Copyright © 2025 Zhang, Li, Wu and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Qiang Guo, ZHVkdXFpYW5nMjAxM0AxNjMuY29t; Haiyang Wu, d3VoYWl5YW5nMjAyMUB0bXUuZWR1LmNu
†These authors have contributed equally to this work