CASE REPORT article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1591365
Early immunotherapy in a patient with myelin oligodendrocyte glycoprotein antibody-associated disease with syphilis and acquired immune deficiency syndrome: A case report
Provisionally accepted
- Tianjin Medical University General Hospital, Tianjin, China
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This is the case of a 41-year-old man who presented with blurred vision, unconsciousness, and fever with a positive Babinski sign on both sides. Blurred vision, unconsciousness, and fever are common complaints in the Department of Neurology and Emergency, with a wide range of potential etiologies. Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) often occurs after infection, but cases of syphilis and human immunodeficiency virus as precursors are rarely reported. We report a case of MOGAD with syphilis and acquired immune deficiency syndrome. Additionally, the study summarizes the disease's clinical manifestations, therapy, prognosis and outcome and highlights the importance of timely and accurate immune regulation therapy.
Keywords: Inflammatory, Central Nervous System, Syphilis, HIV, MOGAD
Received: 08 Apr 2025; Accepted: 30 Jun 2025.
Copyright: © 2025 Zhang, Zhang and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Bin Zhao, Tianjin Medical University General Hospital, Tianjin, China
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