REVIEW article

Front. Immunol.

Sec. Immunological Tolerance and Regulation

Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1592314

Migrasomes: key players in immune regulation and promising medical applications

Provisionally accepted
Shuping  LiShuping LiYanjie  ZhouYanjie ZhouTingting  HuTingting HuMei  LiMei LiYao  LuoYao Luo*Jie  ChenJie Chen*
  • Sichuan University, Chengdu, China

The final, formatted version of the article will be published soon.

Migrasomes are newly discovered extracellular organelles released by migrating cells, such as immune cells, tumor cells, and other special functional cells like podocytes and embryonic cells. They contain a diverse array of constituents, including proteins, lipids, and RNA which can be released to the designated location to activate surrounding cells, thereby facilitating intercellular communication and signal transduction. Since then, our understanding of the mechanism and function of the migrasomes has expanded exponentially, with recent evidence indicating they are involved in various physiological and pathological processes, particularly in immune regulation.Furthermore, methods and techniques for extracting, detecting, and characterizing migrasomes are constantly advancing. Herein, we summarize the current understanding of migrasomes and their key roles in modulating immune responses, as well as the prospective challenges surrounding their clinical application, aiming to provide novel insights into the emerging organelles.

Keywords: migrasomes, Immune Regulation, Biogenesis, intercellular communication, clinical application

Received: 12 Mar 2025; Accepted: 28 Apr 2025.

Copyright: © 2025 Li, Zhou, Hu, Li, Luo and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Yao Luo, Sichuan University, Chengdu, China
Jie Chen, Sichuan University, Chengdu, China

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.