REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1593156
Tumor-associated neutrophils in breast cancer: an angel or a devil?
Provisionally accepted
- 1Southwest Medical University, Luzhou, Sichuan, China
- 2Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, China
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Breast cancer is the most common malignant tumor in women, ranking first globally in both incidence and mortality rates among female malignancies, posing a severe threat to women's physical and mental health . Neutrophils are recognized as the first line of host defense against pathogens and exert beneficial effects in the body.However, emerging evidence has demonstrated that tumor-associated neutrophils (TANs) exhibit a dual role in breast cancer progression and prognosis. Therefore, elucidating their molecular mechanisms may provide novel insights for targeted therapies, potentially improving clinical outcomes for breast cancer patients. This review summarizes the interplay between TANs and breast cancer, their underlying mechanisms, and their potential as immunotherapeutic targets.
Keywords: breast cancer, Tumor-associated neutrophils, immune cell, immune microenvironment, targeted therapy
Received: 13 Mar 2025; Accepted: 14 May 2025.
Copyright: © 2025 Wen, Feng and Fan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yu Fan, Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, China
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