REVIEW article
Front. Immunol.
Sec. T Cell Biology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1593727
This article is part of the Research TopicThe Function and Regulation of T Cell Subsets in Inflammatory DiseaseView all 13 articles
The Immunoregulatory Role of Helper T Cells in Helicobacter pylori Infection
Provisionally accepted
- 1Zunyi Medical University, Zunyi, China
- 2Guizhou Provincial People's Hospital, Guiyang, Guizhou Province, China
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Helicobacter pylori (H. pylori) is a pathogenic bacterium that can survive in the human gastric mucosa and cause chronic infections. More than half of the global population is affected by H. pylori infection, which is closely associated with the development of gastritis, gastric ulcers, gastric cancer, and mucosa -associated lymphoid tissue lymphoma. The immune response triggered by H. pylori infection is complex and involves multiple immune cells. Among them, helper T cells (Th cells) play a crucial role in regulating the immune response. In recent years, researchers have conducted in -depth explorations of the immunoregulatory mechanisms, pathological effects of Th cells in H. pylori infection, and their applications in treatment. However, there are still problems such as insufficient understanding of the functions of Th cell subsets and unclear clinical treatment strategies. This paper aims to review the immunoregulatory role of Th cells in H. pylori infection, analyze their mechanism of action in the pathological process, and explore the future research directions and the development of treatment strategies, providing a theoretical basis for research in this field.
Keywords: Helper T cells, Helicobacter pylori, Immunoregulation, Cytokines, Immune Evasion
Received: 14 Mar 2025; Accepted: 26 May 2025.
Copyright: © 2025 Wu, Gou, Wen, Wang, Liu, Li, Xu and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Rui Xie, Guizhou Provincial People's Hospital, Guiyang, Guizhou Province, China
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