REVIEW article
Front. Immunol.
Sec. Viral Immunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1593885
This article is part of the Research TopicThromboinflammation in COVID-19: Unraveling Pathomechanisms and Post-Infection SequelaeView all 14 articles
COVID-19: A Vascular Nightmare Unfolding
Provisionally accepted
Qinan Yin1
Youjin Huang2Hulin Wang1Yin Wang1
Xuefei Huang2Yujie Song2
Bian Yuan1*
YUEYUAN WANG1*Lizhu Han1*- 1Department of pharmacy, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China
- 2Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan Province, China
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The emergence of COVID-19 has been associated with an increased risk of arteriovenous thrombosis, with immune inflammation playing a significant role in the pathogenesis of thrombosis. Numerous drug-related clinical trials have been undertaken to prevent thrombosis, and guidelines for its prevention and treatment are continuously evolving as our understanding of the disease progresses. This article provides a comprehensive review of the mechanisms underlying thrombosis in COVID-19 patients, as well as the advancements in clinical trials and guidelines for thrombosis prevention with pharmacological interventions.
Keywords: COVID-19, Thrombosis, Mechanism, anticoagulation, Vaccine
Received: 17 Mar 2025; Accepted: 10 Jul 2025.
Copyright: © 2025 Yin, Huang, Wang, Wang, Huang, Song, Yuan, WANG and Han. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Bian Yuan, Department of pharmacy, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China
YUEYUAN WANG, Department of pharmacy, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China
Lizhu Han, Department of pharmacy, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.