MINI REVIEW article
Front. Immunol.
Sec. Molecular Innate Immunity
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1594133
Research and progress of cGAS/STING/NLRP3 signaling pathway:a mini review
Provisionally accepted
- Xiangtan Central Hospital, Xiangtan, China
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Over the past decade, inflammasome and cGAS-STING have received significant attention as immune components that coordinate host immune homeostasis.Although the inflammasome and cGAS-STING are relatively independent immune signaling pathways, some studies have pointed out that there is an important association between cGAS-STING and the inflammasome. As the downstream of cGAS-STING, inflammasome plays an important role in many diseases. In this mini-review, we review the association between CGAS-STING and NLRP3 inflammasome, the progression of the cGAS/STING/NLRP3 signaling pathway in the pathogenesis of disease, the therapeutic strategies that targeted cGAS/STING/NLRP3 signaling pathway. We believe that targeting the cGAS/STING/NLRP3 signaling pathway in the future has broad prospects and significance for the treatment of disease.
Keywords: CGAS, STING, Inflammasome, NLRP3, IFN
Received: 15 Mar 2025; Accepted: 01 May 2025.
Copyright: © 2025 Chen, Tang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ke Qian Chen, Xiangtan Central Hospital, Xiangtan, China
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