REVIEW article
Front. Immunol.
Sec. Multiple Sclerosis and Neuroimmunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1595276
Multiple Sclerosis: Etiology in the context of neurovascular unit and immune system involvement and advancements with in vitro blood-brain barrier models
Provisionally accepted
- Wake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University, Winston-Salem, United States
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Multiple sclerosis affects a significant portion of the world's adult population and is the most common nontraumatic neuroimmunology disorder. Although the specific etiology of multiple sclerosis remains unknown, it has been associated with autoimmune components. While current treatment options relieve some symptoms in MS patients, most are immunosuppressive and only delay the progression of the disease without conferring definitive curative measures. Hence, a thorough understanding of disease pathobiology, the contribution of the neurovascular unit (NVU), and biological body-on-achip systems that replicate the blood-brain barrier may open new horizons for the discovery of potential therapeutics for MS.
Keywords: Multiple sclerosis, autoimme disease, Neuroinf lammation, blood brain barrier, neurovascular unit, In-vitro model
Received: 17 Mar 2025; Accepted: 16 May 2025.
Copyright: © 2025 El-Taibany, Heydarian, Porada, Seeds and Atala. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Aya A. El-Taibany, Wake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University, Winston-Salem, United States
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.