REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1595852
This article is part of the Research TopicNew Strategies for Spinal Cord Injury and Immunotherapy Targeting Novel Programmed Death PathwaysView all 5 articles
The Emerging Role of Cuproptosis in Spinal Cord Injury
Provisionally accepted
- 1Jiangyin People's Hospital, Jiangyin, China
- 2Department of Spinal Surgery, Affiliated Jiangyin Clinical College of Xuzhou Medical University, Jiangyin City, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Copper is a vital trace element integral to numerous biological processes, including iron metabolism, neurotransmitter synthesis, mitochondrial respiration, oxidative stress regulation, and energy production. However, disturbances in copper homeostasis can result in pathological conditions, including cuproptosis-a newly recognized form of programmed cell death marked by copper accumulation and the disruption of copper-dependent metabolic pathways. Cuproptosis has been associated with normal physiology and various diseases, such as cancer, metabolic disorders and neurodegenerative disorders. In the context of spinal cord injury (SCI), multiple pathological mechanisms, including inflammation and oxidative stress, and programmed cell death (PCD) could impact the patient's prognosis with SCI. This review seeks to elucidate the mechanisms and biological significance of copper homeostasis and cuproptosis, the pathophysiological underpinnings of SCI, and the role of cuproptosis in SCI.
Keywords: spinal cord injury, Reactive Oxygen Species, copper homeostasis, cuproptosis, programmed cell death
Received: 18 Mar 2025; Accepted: 26 May 2025.
Copyright: © 2025 Liu, Xu, Hu, Zhou, Deng and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Chao Liu, Jiangyin People's Hospital, Jiangyin, China
Xiongwei Deng, Department of Spinal Surgery, Affiliated Jiangyin Clinical College of Xuzhou Medical University, Jiangyin City, China
Yunrong Zhu, Department of Spinal Surgery, Affiliated Jiangyin Clinical College of Xuzhou Medical University, Jiangyin City, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.