CASE REPORT article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1595947
Severe psoriasis skin lesions following ofatumumab treatment for multiple sclerosis: case report
Provisionally accepted
Wioletta Katarzyna Żukowicz-Wyrwa*
Karolina Markiet
Tatsiana Damps
Aleksandra CiarkaBartosz Karaszewski- Medical University of Gdansk, Gdańsk, Poland
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The article explores a case study of a patient diagnosed with relapsing-remitting multiple sclerosis (RRMS) who, while receiving treatment with the anti-CD20 monoclonal antibody ofatumumab, developed psoriatic skin lesions. Initially, sharply demarcated, scaly, erythematous lesions were observed only in the anogenital area. After several weeks, additional lesions appeared on the ear lobes, scalp, and lower legs following subsequent administrations of ofatumumab. A comprehensive differential diagnosis of the skin lesions was performed, which included consideration of autoimmune chronic diseases, infectious disease manifestations, and skin carcinomas. Biopsies of the lesions were obtained and underwent histopathological examination. Based on the clinical presentation and further investigations, it was concluded that the skin lesions were an atypical adverse reaction to ofatumumab, manifesting as psoriasis. In addition to presenting this case, we analyze the spectrum of common adverse reactions associated with ofatumumab, as well as the occurrence of psoriasis following other anti-CD20 therapies. To the best of our knowledge, this is a rare, documented instance of psoriasis occurring in a patient receiving ofatumumab for the treatment of multiple sclerosis.
Keywords: Multiple Sclerosis, Ofatumumab, Psoriais, Anti-CD 20 antibodies, adverse effect
Received: 18 Mar 2025; Accepted: 17 Jul 2025.
Copyright: © 2025 Żukowicz-Wyrwa, Markiet, Damps, Ciarka and Karaszewski. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wioletta Katarzyna Żukowicz-Wyrwa, Medical University of Gdansk, Gdańsk, Poland
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