CASE REPORT article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1596544
Successful treatment of guselkumab in a patient with verrucous psoriasis unresponsive to secukinumab
Provisionally accepted
- School of Medicine, Tongji University, Shanghai, China
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A 77-year-old Chinese male with a 10-year history of plaque psoriasis had recurrent episodes of symmetric hypertrophic verrucous plaques in the lower legs. The patient was monitored for the evolution of the disease over two years before he came to our attention. Because the lesions were resistant to topical glucocorticoids and vitamin D3 at another dermatological center, the patient was treated with secukinumab for one year. However, the verrucous lesions further worsened, and the patient visited the outpatient department of our hospital in March 2023. Treatment with guselkumab was started. It immediately attenuated the plaques of the trunk and limbs. Surprisingly, the verrucous plaques of both legs showed complete resolution in 6 months.
Keywords: verrucous psoriasis, Plaque psoriasis, secukinumab, guselkumab, case report
Received: 19 Mar 2025; Accepted: 20 Oct 2025.
Copyright: © 2025 Zheng, Xuemei, Shi and Ding. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yuling Shi, shiyuling1973@126.com
Yangfeng Ding, dingyangfeng@hotmail.com
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