ORIGINAL RESEARCH article

Front. Immunol.

Sec. Mucosal Immunity

Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1596746

This article is part of the Research TopicInnovation in the Management of Rhinologic DisordersView all 7 articles

Inflammation-Driven Periostin in ECRS has Contrasting Effects on Tissue Structural Integrity and Osteitis

Provisionally accepted
Soo-In KimSoo-In Kim1,2,3*Min-Seok RhaMin-Seok Rha1,4,5Jinsun KimJinsun Kim1Sang Hyeon AhnSang Hyeon Ahn1,6Ji-Hwan RyuJi-Hwan Ryu1,2,3Hyung-Ju ChoHyung-Ju Cho1,4Chang-Hoon KimChang-Hoon Kim1,4,5*
  • 1The Airway Mucus Institute, Yonsei University College of Medicine, Seoul, Republic of Korea
  • 2Department of Biomedical Sciences, Yonsei University College of Medicine, Seoul, Republic of Korea
  • 3Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea
  • 4Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Republic of Korea
  • 5Human Microbiome Center, Yonsei University College of Medicine, Seoul, Republic of Korea
  • 6Department of Otorhinolaryngology, Bundang Jesaeng Hospital, Seongnam, Republic of Korea

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Eosinophilic chronic rhinosinusitis (ECRS) is a severe form of chronic rhinosinusitis characterized by type 2 inflammation, tissue remodeling, and bone thickening, known as osteitis. Periostin, a matricellular protein involved in extracellular matrix (ECM) regulation and T helper 2 (Th2)mediated inflammation, is markedly elevated in patients with ECRS; however, its pathophysiological role remains unclear. Here, we investigated the function of periostin in inflammation and tissue remodeling in ECRS using patient samples, in vitro models, and a mouse model. Periostin levels were elevated in ECRS tissues and modestly correlated with osteitis scores. Th2 cytokines increased periostin expression, particularly in nasal fibroblasts. Conditioned medium containing periostin promoted osteogenic differentiation in vitro, whereas neutralizing antibodies reduced the expression of osteogenic markers. In an ECRS mouse model, periostin deficiency led to reduced bone thickening and lower expression of osteogenic markers despite similar eosinophil infiltration. Furthermore, periostin-deficient mice exhibited greater epithelial collapse and reduced fibronectin levels, indicating compromised ECM integrity. These findings demonstrate that periostin contributes to

Keywords: periostin, Th2 inflammation, Eosinophilic chronic rhinosinusitis, Osteitis, Tissue remodeling

Received: 20 Mar 2025; Accepted: 30 May 2025.

Copyright: © 2025 Kim, Rha, Kim, Ahn, Ryu, Cho and Kim. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Soo-In Kim, The Airway Mucus Institute, Yonsei University College of Medicine, Seoul, Republic of Korea
Chang-Hoon Kim, The Airway Mucus Institute, Yonsei University College of Medicine, Seoul, Republic of Korea

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