REVIEW article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1597462
This article is part of the Research TopicAutoimmune Diseases: from molecular mechanisms to therapy developmentView all 14 articles
Mechanism of Cell Death and its Application in the Repair of Inflammatory Bowel Disease by Mesenchymal Stem Cells
Provisionally accepted
- 1Jiangsu University, Zhenjiang, Jiangsu Province, China
- 2Danyang People's Hospital, Danyang, Jiangsu Province, China
- 3Jiangsu University Affiliated People's Hospital, Zhenjiang, China
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The onset and progression of inflammatory bowel disease (IBD), which encompasses ulcerative colitis and Crohn's disease, are influenced by the immune system, environmental factors, genetics, and intestinal flora. Cell death is a biological phenomenon that occurs in all living organisms; nevertheless, excessive cell death has been linked to IBD, including increased immune and intestinal epithelial cell death and intestinal barrier abnormalities. Anti-tumor necrosis factor medication, which has made significant progress in treating IBD cell death, may fail in some individuals or lose effectiveness over time, necessitating the search for a safe and effective treatment.One of the novel and emerging areas in regenerative and nanomedicine used to regulate cell death is mesenchymal stem cells (MSCs) and their mediators (extracellular vesicles). MSCs and their mediators have been found to attenuate cell death in several illnesses, including IBD. This review explores cell death mechanisms and their implications in IBD, focusing on the potential ameliorative effects of MSCs and their mediators on cell death.
Keywords: Cell Death, extracellular vesicles, exosome, IBD, MSc
Received: 21 Mar 2025; Accepted: 19 May 2025.
Copyright: © 2025 Akanyibah, He, Cai, Wang, Wang and Mao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Fei Mao, Jiangsu University Affiliated People's Hospital, Zhenjiang, China
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