MINI REVIEW article
Front. Immunol.
Sec. Nutritional Immunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1598804
This article is part of the Research TopicUpping the Heat: Capsaicin for Human HealthView all 3 articles
Role of TRPV1 in Neuroendocrine Regulation: A Potential Target Against Obesity?
Provisionally accepted
- School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China
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Obesity is a common metabolic syndrome in which an imbalance between energy intake and consumption is the main cause of excessive accumulation of body fat. The increasing prevalence of obesity and its associated complications poses significant challenges to public health. Activation of the transient receptor potential vanilloid subtype 1 (TRPV1) cascade plays a key role in lipid metabolism and energy intake.TRPV1 is expressed across the central nervous system and peripheral organs is involved in the regulation of hormone secretion, appetite and mitochondrial function,and is recognized as one of the key targets for preventing obesity. The current treatments for obesity exhibit limited efficacy and are associated with numerous side effects. Targeting TRPV1 represents a potentially effective approach for managing obesity. In this work, by combining the recent mechanism of the role of TRPV1 in neuroendocrine regulation, we hope to provide novel approaches to block or even reverse the development of obesity.
Keywords: Transient receptor potential vanilloid subtype 1 (TRPV1), Obesity, Neuromodulatory mechanisms, Endocrine mechanisms, Energy Metabolism
Received: 24 Mar 2025; Accepted: 19 Jun 2025.
Copyright: © 2025 Wang, Liu, Wen, Xing, Chen, Xia and Ding. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiuwen Xia, School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China
Wei-Jun Ding, School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China
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