REVIEW article
Front. Immunol.
Sec. Cytokines and Soluble Mediators in Immunity
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1599277
This article is part of the Research TopicCytokine Interactions and Biomarker Potential in Various DiseasesView all 4 articles
CCR10: A Comprehensive Review of Its Function, Phylogeny, Role in Immune Cell Trafficking and Disease Pathogenesis
Provisionally accepted
Amanda Lopes WilluveitAna Carolina Buzzo StefaniniTais Aparecida Matozo de Souza
Luciana Cavalheiro Marti*- Peter Murányi Experimental Research Center, Hospital Israelita Albert Einstein, São Paulo, São Paulo, Brazil
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CCR10, the latest classified receptor in the CC chemokine family, plays a critical role in tissue-specific immune responses, particularly in skin and mucosal immunity. By interacting with its ligands, CCL27 and CCL28, it regulates immune cell trafficking, contributing to homeostasis, wound healing, and mucosal defense. However, CCR10 has also been implicated in inflammatory disorders, autoimmune diseases, and cancer progression, where it may facilitate immune evasion and metastasis. Despite its dual roles, CCR10 represents a promising therapeutic target, with potential applications in modulating immune responses for inflammatory diseases and oncology. A deeper understanding of its mechanisms and interactions could provide valuable insights into immune system regulation, disease progression and clinical relevance. This review explores CCR10's molecular structure, biological functions, and potential for therapeutic intervention.
Keywords: chemokine, chemokine receptor, CCR10, CCL27, CCL28
Received: 24 Mar 2025; Accepted: 28 Aug 2025.
Copyright: © 2025 Willuveit, Stefanini, de Souza and Marti. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Luciana Cavalheiro Marti, Peter Murányi Experimental Research Center, Hospital Israelita Albert Einstein, São Paulo, 05652-900, São Paulo, Brazil
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.