REVIEW article
Front. Immunol.
Sec. Molecular Innate Immunity
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1599748
This article is part of the Research TopicInnate Immunity and Metabolic Disorders: Molecular Mechanisms and Therapeutic ImplicationsView all 3 articles
Mechanisms of innate immune cells in Metabolic dysfunction-associated steatotic liver disease
Provisionally accepted
- 1Nankai University, Tianjin, China
- 2Tianjin First Central Hospital, Tianjin, China
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【Abstract】 With the continuous increase of the incidence of Metabolic dysfunction-associated steatotic liver disease(MASLD), the proportion of MASLD-driven hepatocellular carcinoma(HCC) is gradually increasing, which will become a heavy burden on global public health. This article summarizes the existing literature and discusses the role of various innate immune cells in the occurrence and development of MASLD, such as cell-cell crosstalk, and uses bibliometric analysis to find current research hotspots and emerging topics, in order to provide valuable reference for scholars studying the direction of MASLD-driven HCC immunity. It also provides a solid foundation for more researchers to join the research direction. And try to inspire researchers in future research to seek breakthroughs in this regard.
Keywords: MASLD, MASH, HCC, innate immune cells, ATMS
Received: 25 Mar 2025; Accepted: 05 Sep 2025.
Copyright: © 2025 YAO, Sheng, Fan and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: YAO YAO, Nankai University, Tianjin, 300071, China
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