REVIEW article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1604271
Research Progress of SOCS in Autoimmune Diseases: Mechanisms and Therapeutic Implications
Provisionally accepted
Rongqi Cui1
Jing Zhang2*- 1China Medical University, Shenyang, Liaoning Province, China
- 2Sheng Jing Hospital Affiliated, China Medical University, Shenyang, China
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Suppressor of cytokine signaling (SOCS) is a family of regulatory factors whose expression can be induced by various cytokines, growth factors, and hormones. Autoimmune diseases, chronic inflammatory conditions caused by abnormal immune responses, involve overactive T-cells and B-cells, excessive autoantibody production, and damage to multiple organs and systems. The pathogenic mechanisms of autoimmune diseases are complex, and SOCS proteins, particularly SOCS1, SOCS2, SOCS3, and SOCS5, regulate cytokine receptor signaling through distinct mechanisms, thereby participating in the development and progression of autoimmune diseases. This positions SOCS proteins as potential therapeutic targets for modulating dysregulated immune responses in autoimmune diseases.
Keywords: SOCS 1, autoimmune diseases 2, Immunity 3, JAK-STAT 4, Chen Y, Darwiche R, Dudek NL, Irawaty W
Received: 01 Apr 2025; Accepted: 01 Jul 2025.
Copyright: © 2025 Cui and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jing Zhang, Sheng Jing Hospital Affiliated, China Medical University, Shenyang, China
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