ORIGINAL RESEARCH article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1605695
This article is part of the Research TopicTumor-Associated Macrophages and Tumor-Infiltrating Lymphocytes in the Tumor MicroenvironmentView all 8 articles
Research trends and hotspots in the tumor microenvironment of ovarian cancer: A bibliometrics and visualization study from 2005 to 2024
Provisionally accepted
- Affiliated Hospital of Jining Medical University, Jining, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background: The tumor microenvironment (TME) is crucial in influencing the progression and therapeutic response of ovarian cancer. Method: This study conducted a comprehensive bibliometric and visualization analysis of research trends and focal areas concerning the ovarian cancer microenvironment from 2005 to 2024. A total of 1,720 pertinent articles were identified from the Web of Science Core Collection (WoSCC) database. Results: The analysis revealed a notable increase in research activity on the TME of ovarian cancer, particularly during the period from 2019 to 2022. The United States and China were the most active countries in this field, and the University of Texas System was the scientific research institution with the largest number of articles. Cancer Research and Clinical Cancer Research were the most cited journals. Weiping Zou and Anil K Sood were recognized as the most cited researchers. The study systematically identified key research hotspots within this field, encompassing immune checkpoint inhibitors, single-cell RNA sequencing technology, the TME heterogeneity, the TGFβ signaling pathway, and the impact of PARP inhibitors on the tumor immune microenvironment (TIME). Conclusion: This study provides a valuable reference for the evolution and prospective directions of TME research in ovarian cancer, underscoring the critical importance of a comprehensive understanding of the TME to enhance treatment strategies for ovarian cancer.
Keywords: ovarian cancer, Tumor Microenvironment, Bibliometrics, visualization, Research trends, Research hotspots
Received: 03 Apr 2025; Accepted: 11 Aug 2025.
Copyright: © 2025 Wang, Yin, Hou, Yin and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Tao Liu, Affiliated Hospital of Jining Medical University, Jining, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.