ORIGINAL RESEARCH article
Front. Immunol.
Sec. T Cell Biology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1605827
This article is part of the Research TopicThe Function and Regulation of T Cell Subsets in Inflammatory DiseaseView all 13 articles
Single-cell analysis of peripheral blood and pleural effusion reveals functional diversity of γδ T cells in tuberculosis infection
Provisionally accepted
Yanjun Feng1,2
Yu Chen3
Wanying Zhang1,2
Shen Xinghua1,2
Jin Yu Yan1,2Lin Yao1,2Lijuan Zhang1,2Yayan Niu1,2*Jianping Zhang1,2*
Peijun Tang1,2*Chunhua Ling1,2*- 1Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Suzhou Medical College of Soochow University, Suzhou, China
- 2Department of Tuberculosis, The Fifth People’s Hospital of Suzhou & The Affiliated Infectious Diseases Hospital, Suzhou Medical College of Soochow University, Suzhou, China
- 3Department of Biochemistry and Molecular Biology, School of Biology and Basic Medical Sciences, Suzhou Medical College of Soochow University, Suzhou, China
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Tuberculosis is a contagious airborne disease caused by the Mycobacterium tuberculosis infection. γδ T cells are closely associated with TB infection; however, the specific role of γδ T cells in the immune response to TB remains unclear, as does the differentiation and mechanism of γδ T cell subsets in TB patients. We analyzed the characteristics of γδ T subsets in the peripheral blood (Peripheral Blood Mononuclear Cells,PBMC) and pleural effusions (Tuberculous pleural effusion,TPE) and pleural effusions of TB patients using single-cell sequencing to explore the distribution and characteristics of different γδ T subpopulations. Through in-depth analysis, we identified a group of Vδ2 cells exhibiting strong effector function and high expression of FCGR3A.Therefore, exploring the mechanism of interaction between Vδ2 cells and Mtb, as well as understanding host immune regulation during Mtb infection, can not only enhance the understanding of the immune mechanism underlying TB but also provide new theoretical ideas. Furthermore, this research may offer novel therapeutic targets for TB and innovative strategies for treatment and prevention.
Keywords: Tuberculosis, Mycobacterium tuberculosis, γδ T cells, FCGR3a, Single-Cell Analysis
Received: 04 Apr 2025; Accepted: 26 May 2025.
Copyright: © 2025 Feng, Chen, Zhang, Xinghua, Yan, Yao, Zhang, Niu, Zhang, Tang and Ling. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yayan Niu, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Suzhou Medical College of Soochow University, Suzhou, China
Jianping Zhang, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Suzhou Medical College of Soochow University, Suzhou, China
Peijun Tang, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Suzhou Medical College of Soochow University, Suzhou, China
Chunhua Ling, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Suzhou Medical College of Soochow University, Suzhou, China
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