ORIGINAL RESEARCH article
Front. Immunol.
Sec. Nutritional Immunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1606145
Dietary inflammation: a potential driver of atopic dermatitis? --Evidence from KNHANES 2017-2023
Provisionally accepted
- 1Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China
- 2Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China
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The global incidence of atopic dermatitis (AD) has risen significantly in recent decades, with trends showing spatial and temporal coupling with dramatic changes in dietary habits during industrialisation. Although the Dietary Inflammatory Index (DII), a tool to quantify the inflammatory potential of diet, has made breakthroughs in the study of chronic inflammatory diseases, large-scale cross-sectional evidence for its association with AD is still lacking.Health and Nutrition Examination Survey(KNHANES)2017-2023, the association between DII quartiles and AD risk was analysed using weighted multivariate logistic regression, with adjusted odds ratios (aORs) and 95% CIs calculated, stratified by sex (male/female) and age (≤54 vs >54); interactions were assessed by the Wald test, and the association between dietary index and risk was assessed using the Restricted cubic spline(RCS) models (with nodes set at the 10th, 50th, and 90th percentiles of DII) were used to explore non-linear associations, with models adjusted for covariates such as sex, age, and education.Results: Higher DII scores showed a significant association with AD prevalence.Participants in the highest DII quartile had a 73% higher risk than those in the lowest quartile (aOR = 1.73, 95% CI = 1.45-2.07).and the sex interaction was significant (interaction p<0.05), with stronger associations in the female group; RCS analyses showed a possible linear association between DII and AD risk (non-linear p>0.05).High dietary inflammatory index was significantly and positively associated with high prevalence of AD, especially in female and younger age groups; Notably, higher intake of dietary fiber and carotene is associated with a lower prevalence of AD.
Keywords: atopic dermatitis, Dietary patterns, Dietary inflammation index, KNHANES, sex stratification, Age stratification, Restricted cubic spline models
Received: 04 Apr 2025; Accepted: 06 Jun 2025.
Copyright: © 2025 Tan, Sun, Wang, Chen, Long and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Junbin Zhang, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250011, Shandong Province, China
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