REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1606277
This article is part of the Research TopicExploring KLF4's Role in Immune Cell Function and Disease ProgressionView all 3 articles
KLF feedback loops in innate immunity
Provisionally accepted
- 1Australian Centre for Blood Diseases, Central Clinical School, Faculty of Medicine, Nursing & Health Sciences, Monash University, Melbourne, Victoria, Australia
- 2Monash University, Melbourne, Australia
- 3QIMR Berghofer Medical Research Institute, The University of Queensland, Herston, Queensland, Australia
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The Krüppel-like factor (KLF) family of zinc finger transcription factors regulate the expression of genes involved in a wide range of cellular processes, including cell proliferation and differentiation. In haematopoiesis, KLFs have essential roles in myeloid cell differentiation and function. KLF4 is a critical regulator of macrophage development and initiates pro-and antiinflammatory signalling pathways in response to various stimuli. KLF2, KLF3 and KLF6 also play important roles in regulating these pathways. Here we review how KLFs cooperate and compete to either activate or repress target genes to influence initiation and resolution of inflammatory responses in macrophages. We also discuss how KLFs may be involved in the development of chronic inflammatory conditions.
Keywords: macrophage, Inflammation, KLF4, KLF3, Transcriptional regulation, feedback loops, Chronic inflammatory disease, innate immunity
Received: 07 Apr 2025; Accepted: 14 May 2025.
Copyright: © 2025 Salmon, Adams, Magor and Perkins. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Andrew Charles Perkins, Monash University, Melbourne, Australia
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