ORIGINAL RESEARCH article
Front. Immunol.
Sec. T Cell Biology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1607177
PET/CT-Based Prognostic Model Enhances Early Survival Prediction in Angioimmunoblastic T-cell Lymphoma
Provisionally accepted
- Beijing Cancer Hospital, Peking University, Beijing, China
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Background: To develop and validate a new prognostic model using baseline PET parameters and clinical indicators for predicting early overall survival (OS) in Angioimmunoblastic T-cell lymphoma (AITL) patients. Methods: We conducted a retrospective cohort study from December 2009 to December 2023 (n=124) at a single center. The model's predictors included baseline clinical characteristics, pathological indicators, laboratory metrics, and PET/CT parameters. Independent prognostic factors were identified using Cox regression and presented as nomograms. The C-index assessed predictive accuracy, while calibration plots and decision curve analysis evaluated prediction accuracy and discrimination ability. The model's accuracy was compared with existing prognostic systems using C-index, NRI, ROC, and Kaplan-Meier survival curves.Results: SUVmax, β2MG, platelet, and albumin were identified as independent risk factors. The C-index for OS was 0.78 (95% CI: 0.70-0.85); for 1000 bootstrap samples, it was 0.76 (95% CI: 0.61-0.93). Calibration curves showed excellent agreement between predictions and actual observations. The AUC for 6-month and 1-year OS were 0.91(95% CI: 0.82-1.00) and 0.85 (95% CI: 0.77-0.94), respectively. The model outperformed PIAI, IPI, and PIT in predictive capacity.The new prediction model reliably estimates outcomes for AITL patients, demonstrating high discrimination and calibration.
Keywords: Angioimmunoblastic T-cell lymphoma, PET/CT, overall survival, Prediction model, cox regression model
Received: 07 Apr 2025; Accepted: 01 Jul 2025.
Copyright: © 2025 Xu, Ding, Jin, Shi, Yang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Nan Li, Beijing Cancer Hospital, Peking University, Beijing, China
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