REVIEW article
Front. Immunol.
Sec. Antigen Presenting Cell Biology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1607932
m6A modification: a novel mechanism that regulates atherosclerosis via macrophage polarization
Provisionally accepted
- 1Beijing University of Chinese Medicine, Beijing, Beijing Municipality, China
- 2Shanxi Traditional Chinese Medical Hospital, Taiyuan, Shanxi Province, China
- 3Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
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Atherosclerosis is a chronic vascular inflammatory disease in which macrophages play a pivotal role in modulating its pathology. In response to the intraplaque microenvironment, both pro-inflammatory M1 and anti-inflammatory M2 phenotypes of macrophages have the polarization capability, each influencing the inflammatory state through the secretion of distinct cytokines.N6-methyladenosine (m6A) modification, the most prevalent internal chemical modification of RNA, significantly impacts various biological processes, including RNA transcription and protein expression. m6A modification acts as a critical determinant in macrophage polarization, with its molecular mechanisms intricately linked to the progression of atherosclerosis. This review aims to elucidate how different macrophage polarization phenotypes influence the progression of atherosclerosis while also exploring the significance of m6A modifications in this pathological context, thereby providing a theoretical foundation for identifying novel diagnostic and therapeutic targets for atherosclerosis.
Keywords: Macrophage polarization, Cytokines, Atherosclerosis, N 6 -methyladenosine modification, Inflammatory
Received: 08 Apr 2025; Accepted: 29 May 2025.
Copyright: © 2025 Li, Zhang, Yan, Zhang and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ye Huang, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.