REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1608353
This article is part of the Research TopicNeuroinflammation: Mechanisms and Therapeutic InterventionsView all 19 articles
The role of inflammation in Ischemic stroke: From biomarker to treatment
Provisionally accepted
- 1Changsha Hospital of Traditional Chinese Medicine, Changsha, Hunan Province, China
- 2Hunan Hospital of Integrated Traditional Chinese and Western Medicine, Changsha, Anhui Province, China
- 3Hunan University of Chinese Medicine, Changsha, Anhui Province, China
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Stroke ranks among the most prevalent diseases globally. Ischemic stroke (IS), constituting 87% of all strokes, poses a significant threat to patients' health. Following the onset of IS, within a few minutes, inflammation is initiated. This inflammation activates immune cells and related signaling pathways, further exacerbating the inflammatory state, eventually leading to irreversible brain injury. Therefore, regulating the inflammatory response can contribute to the treatment of IS.This review delves into the inflammatory mechanism in IS, the role of inflammatory markers, and the research advancements regarding the use of inflammatory markers in treatment. While previous studies often concentrated on a single aspect of the inflammatory mechanism or specific inflammatory markers, this review systematically synthesizes the fragmented information. It offers readers a comprehensive and coherent view, facilitating an in - depth comprehension of the complexity of the inflammatory response in IS. This article not only expounds the value of inflammatory markers in disease diagnosis and prognosis, but also highlights the research progress including traditional Chinese medicine treatment. This has important guiding significance for clinicians to formulate precise treatment plans, and provides a variety of options for clinical practice.The research progress of these treatment strategies presents new opportunities for addressing the challenges in IS treatment, with the potential to improve patients' prognosis and quality of life. Through a comprehensive overview of inflammation - related studies in IS, this review serves as a valuable reference for research and clinical practice in this field, contributing to the further development of IS treatment research.
Keywords: stroke1, ischemic stroke2, inflammation3, Biomarker4, TCM5
Received: 08 Apr 2025; Accepted: 03 Sep 2025.
Copyright: © 2025 Xiao, Huang, Wu, Zeng, Qiu, Li, Xie and Dahua. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wu Dahua, Hunan Hospital of Integrated Traditional Chinese and Western Medicine, Changsha, Anhui Province, China
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