REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1609596
This article is part of the Research TopicInterplay of Epigenetic Regulation and Cellular Metabolism in Cancer MicroenvironmentsView all 8 articles
Lactylation in tumor: mechanisms and therapeutic potentials
Provisionally accepted
- Department of Thoracic Surgery, Sichuan Cancer Hospital, Chengdu, China
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Lactate, a central product of glucose metabolism, plays a vital role in energy supply and signal transduction, and it also participates in gene transcription regulation through lactylation. Metabolic reprogramming is a key feature of tumor cells and highlights the important role of lactylation in cancer development. Recent studies have emphasized the significant regulatory roles of lactylation in cancer, suggesting that it may serve as a potential target for treatment. This review discusses the mechanisms, regulation, and functions of lactylation in cancer. It also explores the possible significance of lactylation as a marker for the diagnosis and therapy of tumor, and evaluates the therapeutic prospects of targeting lactylation. While the precise mechanisms of lactylation in cancer regulation require further investigation, its significant influence indicates promising avenues for future research.
Keywords: Lactate, lactylation, post-translational modifications, tumor metabolism, Tumor Microenvironment
Received: 10 Apr 2025; Accepted: 30 May 2025.
Copyright: © 2025 Wang, Rong, Ma and Peng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ke Ma, Department of Thoracic Surgery, Sichuan Cancer Hospital, Chengdu, China
Jun Peng, Department of Thoracic Surgery, Sichuan Cancer Hospital, Chengdu, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.