REVIEW article
Front. Immunol.
Sec. Microbial Immunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1609960
This article is part of the Research TopicHost and Microbe Immunometabolic Chat: A New Era of Organismal CommunicationView all 7 articles
The Role of the Microbiome on Immune Homeostasis of the Host Nervous System
Provisionally accepted
- 1Shenzhen Longhua District Central Hospital, Shenzhen, China
- 2Futian District Center for Chronic Disease Control, Shenzhen, Shenzhen, China
- 3Shenzhen University, Shenzhen, Guangdong Province, China
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The gut microbiota is often termed the "second genome" of the human body. It has been shown to be one of the most significant environmental factors (non-genetic) influencing the onset, progression, and prognosis of various neurological and psychiatric disorders through its interactions with the host immune, nervous, and endocrine systems.Changes in the function and composition of the gut microbiota are strongly associated with amyotrophic lateral sclerosis, autism spectrum disorder, depression, Parkinson's disease, and Alzheimer's disease. This review summarizes the research regarding the associations and regulatory mechanisms between the gut microbiota and the central nervous system in order to explore the role of the gut microbiota in maintaining neural homeostasis.
Keywords: Gut Microbiota, Microglia, Microbiota-gut-brain axis, Aromatic compounds, Neuroinflammation
Received: 11 Apr 2025; Accepted: 15 Jul 2025.
Copyright: © 2025 Wang, Zhao, Fu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaokang Wang, Shenzhen Longhua District Central Hospital, Shenzhen, 518110, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.