REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1610119
This article is part of the Research TopicThe Role of Immune Cells in Tissue Regeneration: Mechanisms and Therapeutic InsightsView all 4 articles
Regenerative potential of immune cells after traumatic muscle injury
Provisionally accepted
- Anhui University of Chinese Medicine, Hefei, Anhui Province, China
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Traumatic muscle injury (TMI) causes significant morbidity and socioeconomic burden. Immune cells are central to the subsequent regenerative response, orchestrating dynamic interactions between innate and adaptive immunity. This review systematically summarizes the current understanding of the roles of key immune cells (neutrophils, macrophages, eosinophils, basophils, T lymphocytes, B lymphocytes) in TMI pathophysiology and repair, based on a comprehensive analysis of recent literature. Their intrinsic mechanisms, contributions to tissue regeneration, and therapeutic implications are discussed. Furthermore, we explore therapeutic strategies targeting immune cells, including biomaterials, pharmacologic interventions, cell therapies, and physical modalities. The aim of this review is to provide a consolidated understanding of immune-mediated repair mechanisms in TMI and to identify critical knowledge gaps and future research directions necessary for developing novel immunomodulatory therapies to optimize muscle regeneration and functional recovery.
Keywords: Traumatic muscle injury, immune cell, Neutrophil, macrophage, T lymphocytes
Received: 11 Apr 2025; Accepted: 27 Aug 2025.
Copyright: © 2025 Pu, Hu, Cao, Guoming and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yuqing Wang, Anhui University of Chinese Medicine, Hefei, 230038, Anhui Province, China
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