CASE REPORT article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1610530
Case Reports: Subcutaneous ofatumumab for Patients with Immunosuppressant-Dependent or Ineffective Primary Membranous Nephropathy
Provisionally accepted
- 1Department of Nephrology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China
- 2Liaoning Electric Power Energy Development Group Supervision Co., Ltd., Shenyang, Liaoning Province, China
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CD20 monoclonal antibodies (mAbs), particularly rituximab, have become a preferred treatment for many patients with phospholipase A2 receptor (PLA2R)-related membranous nephropathy (MN). However, some patients either fail to respond to rituximab or experience adverse reactions, indicating that newer-generation CD20 mAbs may offer a more effective alternative. Recently, subcutaneous ofatumumab has been utilized in the treatment of relapsing multiple sclerosis (RMS). This study presents two patients of primary membranous nephropathy (PMN) patients who were treated with subcutaneous ofatumumab. One patient was unresponsive to immunosuppressive therapies, while the other experienced recurrence after drug withdrawal. After ofatumumab therapy, Case 1 achieved PLA2R antibody negativity, and Case 2 showed improvements in renal function and hypoproteinemia. Both cases experienced a reduction in proteinuria. No adverse reactions were reported during the observation period. In conclusion, this study highlights the efficacy and safety of subcutaneous ofatumumab in treating PMN, particularly in patients who have failed or relapsed after conventional therapies.
Keywords: Ofatumumab, Membrane Nephropathy, PLA2R antibody, Subcutaenous administration, CD 20 monoclonal antibody
Received: 12 Apr 2025; Accepted: 13 Jun 2025.
Copyright: © 2025 Chen, Li, Feng and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Bei-Ru Zhang, Department of Nephrology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China
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