MINI REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1611299
This article is part of the Research TopicNanomaterials Mediated Immunomodulation in Cancer: Current Perspective from Bench to ClinicView all articles
Boosting Cancer Immunotherapy: Drug Delivery Systems Leveraging Ferroptosis and Immune Checkpoint Blockade
Provisionally accepted
- 1First People's Hospital of Wenling, Wenling, China
- 2Beihua University, Jilin, Jilin Province, China
- 3Taizhou University, Taizhou, China
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Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, significantly improving outcomes for various malignancies. Despite their clinical success, only a subset of patients benefits from ICIs treatment, underscoring the need for innovative strategies to enhance their therapeutic potential. Ferroptosis, a unique form of programmed cell death driven by iron-dependent lipid peroxidation, has emerged as a promising partner for enhanced immunotherapy. Combining ferroptosis inducers with immune checkpoint blockade has shown promising potential in improving the efficacy of cancer immunotherapy. This study explores the mechanisms of ferroptosis and immune checkpoint inhibitors for synergistic cancer treatment, and reviews recent delivery platforms integrating ferroptosis and immune checkpoint blockade for enhanced therapy.
Keywords: Immune checkpoint inhibitor, ferroptosis, Drug delivery, Immunotherapy, combination therapy
Received: 14 Apr 2025; Accepted: 11 Jun 2025.
Copyright: © 2025 Zhang, Gu, Lin, Shao, Jiang and Guan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xingang Guan, Taizhou University, Taizhou, China
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