ORIGINAL RESEARCH article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1611867
This article is part of the Research TopicNovel Biomarkers for Early Diagnosis, involved in Autoimmune and Autoinflammatory DiseasesView all 16 articles
Association between neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) and psoriasis risk: A nationally representative crosssectional study
Provisionally accepted
- 1Department of Pediatric Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou, China
- 2Guangzhou Medical University, Guangzhou, Guangdong Province, China
- 3Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong Province, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Objective: To investigate the association between the neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) and the risk of psoriasis. Methods: This cross-sectional study analyzed data from the National Health and Nutrition Examination Survey (NHANES) for the periods 2003-2006 and 2009-2014, including 21,723 adults aged ≥20 years. Weighted multivariable logistic regression models were used to examine the association between NHR and psoriasis, with stepwise adjustments for demographic, metabolic parameters, and comorbid factors. Subgroup analyses, sensitivity analyses and smoothed curve fitting were conducted to assess the robustness and potential nonlinearity of the association. Results: The prevalence of psoriasis was 2.75%. Multivariable regression revealed a significant positive association between elevated NHR levels and psoriasis risk (unadjusted model: OR = 1.11, 95% CI = 1.06-1.16, p < 0.001; fully adjusted model: OR = 1.08, 95% CI = 1.02-1.14, p = 0.007). Participants in the highest NHR quartile (Q4) exhibited a 63% higher risk of psoriasis compared to those in the lowest quartile Q1 (OR = 1.63, 95% CI = 1.27-2.08, p < 0.001). Subgroup analyses demonstrated consistent associations across most strata, although the relationship was significantly modified by alcohol consumption history (p for interaction = 0.048). The sensitivity analyses substantiate NHR as a temporally stable and confounder-independent biomarker for psoriasis risk, as evidenced by consistent effect estimates across multiple analytical models and population strata. Conclusion: Higher NHR levels are independently associated with an increased risk of psoriasis. Further prospective cohort studies and mechanistic experiments are needed to validate its predictive performance and potential role in psoriasis risk stratification and monitoring.
Keywords: psoriasis1, NHR2, High-density lipoprotein cholesterol 3, cross-sectional study4, National Health and Nutrition Examination Survey5
Received: 15 Apr 2025; Accepted: 25 Jul 2025.
Copyright: © 2025 Liang, Huang, Li, Si and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wenyue Si, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, 510623, Guangdong Province, China
Kaiying Yang, Department of Pediatric Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.