REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1612032
This article is part of the Research TopicCommunity Series in Immune Responses Against Tumors - From the Bench to the Bedside: Volume IIView all 6 articles
T cell subsets in cervical cancer tumor microenvironment: advances and therapeutic opportunities
Provisionally accepted
- Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Cervical cancer is the third most common malignancy among Chinese women in both incidence and mortality. Its progression is closely linked to complex interactions among immune cells within the tumor microenvironment (TME). As key components of the immune landscape, different T cell subsets play diverse and dynamic roles in shaping tumor immunity. This review provides a comprehensive overview of the roles of various T cell subsets in the TME of cervical cancer, with a focus on their distribution, functional heterogeneity, dynamic balance, and variations across different pathological subtypes and disease stages. We also highlight the intricate crosstalk between T cells and other immune cells in the TME and discuss recent advances in T cell-related immunotherapies for cervical cancer, including immune checkpoint inhibitors and HPV-targeted vaccines. By elucidating the roles of distinct T cell subsets and relevant immunotherapeutic approaches within the TME, this review provides insights into potential therapeutic targets and approaches for improving cervical cancer treatment and patient outcome.
Keywords: T cell, Tumor microenvironment (TME), cervical cancer, Immune Regulation, Immunotherapy
Received: 15 Apr 2025; Accepted: 22 May 2025.
Copyright: © 2025 Guo, Dai and Qiu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Lan Dai, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Lihua Qiu, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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