BRIEF RESEARCH REPORT article
Front. Immunol.
Sec. Vaccines and Molecular Therapeutics
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1612205
This article is part of the Research TopicVaccines and Breakthrough InfectionsView all 11 articles
Hypertension Attenuates COVID-19 Vaccine Protection in Elderly Patients: A Retrospective Cohort Study
Provisionally accepted
- 1University of Macau, Taipa, Macau Region, China
- 2Kiang Wu Hospital, Macau, Macau, Macao, SAR China
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The COVID-19 pandemic has severely impacted elderly populations, particularly those with comorbidities. This study evaluated the effects of COVID-19 vaccination on 193 hospitalized elderly patients (≥ 60 years) in Macao. Vaccination was suggestively associated with a 2.3-fold higher likelihood of prognostic improvement (adjusted OR = 2.3, 95% CI: 0.980-5.940, P = 0.065), while hypertension significantly reduced the improvement rate by 67.5% (P = 0.039). Vaccinated patients also exhibited lower Modified Early Warning Scores and reduced mortality. These findings underscore the protective role of vaccination in improving prognosis among high-risk elderly patients and highlight the need for tailored strategies for those with comorbidities.
Keywords: COVID-19, Vaccination, prognosis, elderly patients, comorbidities
Received: 15 Apr 2025; Accepted: 03 Jul 2025.
Copyright: © 2025 Yuan, Wong, Xu, Zhang and Lei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chon Lok Lei, University of Macau, Taipa, 999078, Macau Region, China
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