REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1613716
MiRNA-Loaded MSC Exosomes Restore Autophagy Flux for Acute Pancreatitis Therapy
Provisionally accepted
- 1Guangdong Medical University, Zhanjiang, China
- 2Meizhou People's Hospital, Meizhou, Guangdong Province, China
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Acute pancreatitis (AP) is an unpredictable and potentially fatal disease. Currently, it is believed that the pathological mechanism of AP is closely related to autophagy imbalance, abnormal activation of inflammatory signals, and impairments in cell damage repair. Autophagy exhibits a double-edged sword effect of "activation accompanied by flux impairment" in AP. In this article, a systematic review is conducted on how mesenchymal stem cells (MSCs) and their secreted exosomes deliver functional miRNAs, targeting and regulating pathways such as PI3K/AKT/mTOR to achieve multiple effects including anti-inflammation, regeneration promotion, and restoration of autophagy homeostasis, providing new strategies for AP treatment (Fig. 1). Current research challenges focus on the standardization of exosome preparation, optimization of miRNA delivery efficiency, and longterm safety evaluation. Further elucidation of the "cell-vesicle-miRNA-target pathway" cascade network, combined with multi-omics technology to develop precise intervention programs, is needed to advance AP treatment from mechanistic exploration to clinical translation.
Keywords: acute pancreatitis, Autophagy, miRNA, Exosomes, signaling pathway
Received: 06 May 2025; Accepted: 14 Jul 2025.
Copyright: © 2025 Zeng, Wu, Luo and Zeng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Haojie Zeng, Guangdong Medical University, Zhanjiang, China
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