ORIGINAL RESEARCH article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1614613
This article is part of the Research TopicColorectal Cancer Immunotherapy and Immune MechanismsView all 8 articles
A Bibliometric Analysis of Immune Escape in Colorectal Cancer: Research Trends, Key Contributors, and Future Directions
Provisionally accepted
- Beijing Daxing District Hospital of Integrated Chinese and Western Medicine, Beijing, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background: Colorectal cancer (CRC) has brought a serious disease burden to the whole world. Immune escape not only promotes the growth and metastasis of CRC, but also limits the effect of immunotherapy. The purpose of this study is to clarify the research status of immune escape in CRC through bibliometrics. Methods: This analysis examined publications on immune escape in CRC from the Web of Science Core Collection. The time limit is 2015-2024. After searching and screening by two researchers, data were collected and various analysis were conducted using tools such as VOSviewer, CiteSpace, and bibliometrix. By analyzing the large-scale existing literature data and using the quantitative method of bibliometric analysis, the research trends and emerging topics can be effectively identified. Results: A total of 573 articles and reviews were included. From 2015-2024, the annual growth rate of 15.93%. The research from China is the most (50.09%), but the research from the United States and Germany is cited more times. Frontiers in Immunology has published the most articles (6.46%). Lei Wang and Peter J.K. Kuppen have made notable contributions, with substantial international collaboration. Keyword analysis highlights research hotspots such as tumor microenvironment and immune-related signaling pathways. Conclusion: The latest research status of immune escape in CRC is shown. Understanding the immune escape mechanism is very important for understanding the occurrence and development of CRC and developing effective immunotherapy strategies. Future research directions include integrating multiple databases to reduce biases inherent in single-database analyses and employing machine learning methods to predict emerging research hotspots, thus providing actionable insights into the dynamic landscape of immune escape research in CRC.
Keywords: immune escape, colorectal cancer, bibliometric analysis, Immunotherapy, Tumor Microenvironment
Received: 19 Apr 2025; Accepted: 02 Jun 2025.
Copyright: © 2025 Zha, He and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chunguang Li, Beijing Daxing District Hospital of Integrated Chinese and Western Medicine, Beijing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.