REVIEW article
Front. Immunol.
Sec. Viral Immunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1614794
This article is part of the Research TopicAnimal-borne viral disease: Pathogenesis, Innate immunity, Acquired immunity, and Novel vaccine developmentView all 13 articles
Exploring the Genetic Basis of Newcastle Disease Virus in Chickens: A comprehensive review
Provisionally accepted
- Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, China
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Newcastle disease (ND) is one of the most serious viral diseases affecting chickens and is caused by Newcastle disease virus (NDV), an avian paramyxovirus serotype-1. The virus contains five structural proteins and two nonstructural proteins that interact with the host proteins involved in viral infection and host antiviral responses. Currently, several NDV strains have been molecularly characterized; however, a comprehensive overview of NDV in chickens that addresses recent findings is lacking. This review summarizes the current report of the molecular structure of NDV, including candidate genes and genomic regions, virulence and route of infection, mechanisms of resistance, host immune response, disease resistance mechanisms and effects of NDV on chicken immune performance. Therefore, this review can be used by researchers seeking a comprehensive understanding that can be applied in future breeding programs aimed at enhancing disease resistance.
Keywords: chicken, immune response, molecular structure, NDV, pathogenesis and genetic resistance
Received: 19 Apr 2025; Accepted: 04 Jun 2025.
Copyright: © 2025 Berihulay, Luo, Lao, Ji, Cai, Shu and Luo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chenglong Luo, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, China
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