REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1614815
This article is part of the Research TopicCancer Metastases: Mechanisms of Tumor Dissemination, Formation of Metastatic Niche and Anti-metastatic TherapyView all 13 articles
Crosstalk Between Stromal, Immune, and Ovarian Cancer Cells in Lipid-Rich Tumor Microenvironment Exhibits Proliferative Features
Provisionally accepted
- China Medical University, Shenyang, China
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Lipid metabolism reprogramming has long been noticed as the hallmark of ovarian cancer, in order to maintain proliferative features including rapid cell division, metastasis capability, and chemotherapy resistance, as well as to survive under environmental stress, alteration of lipid metabolic pathways takes place, especially over-expression of rate-limiting enzymes, enhances lipid uptake, fatty acid synthesis, β-oxidation, lipid storage, and cellular membrane construction. In lipid-rich ascites and omental tumor microenvironments, the biological functions of stromal and immune cells change, forming a premetastatic niche and immunosuppressive tumor microenvironment via modifying extracellular matrix components and secreting cytokines. The crosstalk between stromal, immune, and ovarian cancer cells results in tumor proliferation, metastasis, and escape of immune surveillance. Given the importance of lipid metabolism for ovarian cancer survival, targeting lipid metabolism key enzymes in ovarian cancer or stromal tumor microenvironment may bring novel insights for ovarian cancer treatment.
Keywords: Lipid Metabolism, ovarian cancer, stromal tumor microenvironment, immune response, immunosuppresive TME
Received: 19 Apr 2025; Accepted: 10 Jun 2025.
Copyright: © 2025 Ma, Kang, Guan, Chang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shijie Chang, China Medical University, Shenyang, China
Shuo Li, China Medical University, Shenyang, China
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