REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1616414
This article is part of the Research TopicCommunity Series in Methods in Cancer Immunity and Immunotherapy: Volume IIView all 9 articles
Emerging Strategies in Colorectal Cancer Immunotherapy: Enhancing Efficacy and Survival
Provisionally accepted
- Yan'an University, Yan'an, Shaanxi Province, China
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Colorectal cancer (CRC) is a prevalent malignancy of the digestive system, with metastatic CRC (mCRC) exhibiting persistently poor overall survival rates.Consequently, there is an urgent need to develop more effective and safer therapeutic strategies. In recent years, immunotherapy has emerged as a groundbreaking approach in CRC treatment. This review highlights the advancements in immune checkpoint Inhibitors (ICIs), cancer vaccines, oncolytic virotherapy, adoptive cell therapy(ACT), and matrix-depletion therapy. Additionally, we explore potential combinatorial immunotherapy strategies for CRC, emphasizing their clinical applications and addressing the challenges associated with CRC immunotherapy. By proposing strategies to overcome these limitations, this review aims to provide novel insights into the evolving landscape of CRC immunotherapy.
Keywords: colorectal cancer immunotherapy, immune checkpoint inhibitors, Cancer Vaccines, adoptive cell therapy, matrix-depletion therapy
Received: 22 Apr 2025; Accepted: 17 Sep 2025.
Copyright: © 2025 Zhang, Guan, Feng, Liu, Shao, Liu, He, Jin and Zheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chunli Zheng, chunlizheng@126.com
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