ORIGINAL RESEARCH article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1616924
This article is part of the Research TopicBiomarkers and Beyond: Predicting Course and Tailoring Treatment in Inflammatory Bowel DiseasesView all 12 articles
The role of vitamin D deficiency and modifiable risk factors in patients with Crohn's disease
Provisionally accepted
- Affiliated Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China
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Vitamin D insufficiency is usually seen in Crohn's disease (CD). Our study aims to determine the risk factors for vitamin D insufficiency in CD patients.Between May 2021 and December 2023, we enrolled 102 CD patients and 100 healthy people in our hospital who were eligible for the study. Changes in vitamin D levels were also analyzed. CD patients were divided into active and clinical remission, and further changes in micronutrient and vitamin D levels were analyzed. Lastly, risk factor analysis was conducted using univariate, multivariate, and LASSO regression analysis models.The average age of CD patients was 38.91±3.31 years, whereas the average age of the healthy people was 38.64±2.26 years. Vitamin D levels were significantly lower in CD patients than in healthy controls (19.62±2.68 vs. 22.68±4.61), especially for patients with active CD. In 11 patients treated with vedolizumab, compared to the pre-treatment Vedolizumab group, vitamin D levels improved more dramatically post-Vedolizumab therapy. According to univariate analysis, Age (OR: 0.95, 95% CI 0.26-1.33, p=0.01), sex (OR: 0.26, 95% CI 0.25-0.99, p=0.03), recent biologics (OR: 0.54, 95% CI 0.44-1.25, p=0.02), iron (OR: 0.89, 95% CI 0.72-1.62, p=0.02), and total 25-OH vitamin D (OR:1.25, 95% CI 1.02-1.99, p=0.02) did significantly differ between patients with and without vitamin D deficiency. After controlling for several variables, multivariate analysis revealed that a lower odds ratio was linked to increasing age at diagnosis (OR: 0.12, 95% CI 0.03-0.85, p=0.02), sex (OR: 0.58, 95% CI 0.44-0.95, p=0.01), iron (OR: 0.44, 95% CI 0.11-0.62, p=0.01), and 25-OH vitamin D total (OR: 0.48, 95% CI 0.25-0.95, p=0.03). In addition, Age, time since illness onset, and 25-OH vitamin D were found to be helpful indicators for CD patients using LASSO regression.According to this study, vitamin D insufficiency was often linked to CD patients with active status and pre-treatment Vedolizumab. Furthermore, Age, time since illness onset, and 25-OH vitamin D were found to be significant risk factors for CD.
Keywords: Vitamin D, Crohn's disease, Vedolizumab, age, LASSO regression analysis 47
Received: 23 Apr 2025; Accepted: 10 Jul 2025.
Copyright: © 2025 Feng, Yin, Kang, Jiang, Xu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Fangyu Wang, Affiliated Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China
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