REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1618424
This article is part of the Research TopicImmunological Aspects of Fibrosis Pathogenesis: Novel Mechanisms and Therapeutic StrategiesView all 23 articles
Targeting E3 Ubiquitin Ligases: A New Frontier in Idiopathic Pulmonary Fibrosis Treatment
Provisionally accepted
- Shandong Provincial Hospital, Jinan, China
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Ubiquitination is a modification prevalent in eukaryotic cells. Disruptions in ubiquitination processes can have detrimental effects, potentially leading to diseases that endanger life. E3 ubiquitin ligases specifically recognize substrate proteins during ubiquitin modification, regulating intracellular protein levels and functions through the ubiquitin-proteasome pathway or TGF-β signal transduction. In recent years, substantial evidence has emerged, emphasizing the pivotal role that E3 ubiquitin ligases play in the development of pulmonary fibrosis. Advancing our understanding of how E3 ubiquitin ligases interact with pulmonary fibrosis could reveal new therapeutic targets and treatments for idiopathic pulmonary fibrosis (IPF), as well as innovative approaches in diagnosis and therapy. This review explores known regulatory mechanisms and identifies E3 ligases that have been implicated in IPF development.
Keywords: Idiopathic Pulmonary Fibrosis, E3 ubiquitin ligase, Transforming growth factorβ, Epithelial -mesenchymal transition, profibrotic fibroblast
Received: 26 Apr 2025; Accepted: 28 Jul 2025.
Copyright: © 2025 Zhang, Yuan and Shi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Kun Zhang, Shandong Provincial Hospital, Jinan, China
Hui Yuan, Shandong Provincial Hospital, Jinan, China
Lin Shi, Shandong Provincial Hospital, Jinan, China
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