MINI REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1619100
This article is part of the Research TopicThe Role of the Inflammatory Response in Cell Reprogramming and TransdifferentiationView all 3 articles
Histone Variants: Key Regulators of Inflammation in Cell Dedifferentiation and Transdifferentiation
Provisionally accepted
Manlio Vinciguerra*
Desislava K Tsoneva- Medical University of Varna, Varna, Bulgaria
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Histone variants are specialized isoforms of histone proteins that play crucial roles in regulating chromatin structure and function, influencing transcription, DNA repair, and cell cycle progression. Their dynamic incorporation into nucleosomes impacts gene expression and cellular identity, particularly in the context of inflammation during cell dedifferentiation and transdifferentiation. This mini-review provides a comprehensive overview of the role of histone variants in these processes, highlighting their significance in modulating inflammatory responses and cellular plasticity. We discuss mechanisms by which histone variants influence chromatin architecture and gene regulation, the interplay between histone variants and inflammatory pathways, and the specific roles of key histone variants such as H3.3, H2A.Z, and MacroH2A in dedifferentiation and transdifferentiation. Additionally, we explore the potential therapeutic implications of targeting histone variants to modulate inflammation and cellular plasticity in diseases like cancer and chronic inflammatory conditions. By summarizing existing knowledge and identifying gaps in understanding, this review underscores the importance of histone variants in inflammation-related cell plasticity and suggests future research directions further elucidating their roles and therapeutic potential.
Keywords: histone variants, Inflammation, differentiation, Stem Cells, epigenetics
Received: 27 Apr 2025; Accepted: 16 Jun 2025.
Copyright: © 2025 Vinciguerra and Tsoneva. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Manlio Vinciguerra, Medical University of Varna, Varna, Bulgaria
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