ORIGINAL RESEARCH article
Front. Immunol.
Sec. Alloimmunity and Transplantation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1619291
Worldwide Hotspots and Trends in Stem Cell Therapy for Kidney Disease in the Last Decade: A Bibliometric and Visualization Analysis From 2015 to 2024
Provisionally accepted
- 1Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
- 2Department of Nephrology, Seventh People's Hospital of Shanghai, Shanghai, Shanghai Municipality, China
- 3Department of Endocrinology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
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Background: Kidney disease represents a significant global health concern. Stem cell therapy has gained attention as a potential solution for chronic kidney disease, acute kidney injury, and end-stage renal disease. This study aims to provide a comprehensive overview of the status of stem cell therapy for kidney disease through a systematic review of the literature.The literature included in this study was exclusively sourced from the Web of Science Core Collection. CiteSpace, VOSviewer, R-Bibliometrix, and the Literature Data Governance and Analysis System to evaluate factors such as publication quantity, author contributions, institutional involvement, geographic distribution, and keyword usage.Results: This study on stem cell therapy for kidney disease included 1,874 articles. A significant number of publications came from China and the United States. The Mayo Clinic had the highest publication output, while Stem Cell Research & Therapy was the leading journal in terms of publication volume. Additionally, Lerman LO was the most prolific author in this field. Currently, there is a growing focus on mesenchymal stem cells and acute kidney injury models in this field. Future research is likely to explore topics such as extracellular vesicle-based therapies, various stem cell types, diabetic nephropathy, and membranous nephropathy.This study applied bibliometric methods to assess the application and development of stem cell therapy for kidney disease over the past decade. It identified key research areas and forecasted future trends. The findings offer valuable insights for guiding future investigations into stem cell therapy for kidney disease.
Keywords: kidney disease, kidney injury, nephropathy, stem cell, Bibliometric
Received: 28 Apr 2025; Accepted: 04 Jul 2025.
Copyright: © 2025 Liao, Zhang, Zhou, Wang, Chen, Ye, Zhou and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yuan Zhou, Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
Chen Wang, Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.