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ORIGINAL RESEARCH article

Front. Immunol.

Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1619832

This article is part of the Research TopicNew Insights into Inflammation Driven Autoimmune Skin Disorders: Trends and ChallengesView all 7 articles

Pustular reaction in adult-onset immunodeficiency due to anti-interferon-gamma autoantibodies

Provisionally accepted
Narachai JulanonNarachai Julanon1Pojsakorn DanpanichkulPojsakorn Danpanichkul2Charoen ChoonhakarnCharoen Choonhakarn1Suteeraporn ChaowattanapanitSuteeraporn Chaowattanapanit1Siriluck AnunnatsiriSiriluck Anunnatsiri1Ploenchan ChetchotisakdPloenchan Chetchotisakd1Salin KiratikanonSalin Kiratikanon3Rujira RujiwetpongstornRujira Rujiwetpongstorn3Napatra TovanabutraNapatra Tovanabutra3Siri ChiewchanvitSiri Chiewchanvit3Romanee ChaiwarithRomanee Chaiwarith3Phichayut PhinyoPhichayut Phinyo3Mati ChuamanochanMati Chuamanochan3*
  • 1Khon Kaen University, Khon Kaen, Thailand
  • 2Texas Tech University Health Sciences Center, Texas, United States
  • 3Chiang Mai University, Chiang Mai, Thailand

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Introduction: Cutaneous manifestations in adult-onset immunodeficiency (AOID) resulting from antiinterferon-gamma autoantibody (AIGA) are prevalent and can be classified into infective and reactive disorders. To date, no clinical studies have specifically examined pustular reaction in patients with AOID.This study aimed to provide an original characterization of the clinical manifestations associated with pustular reaction in AOID and to compare these features with those observed in a clinically similar entity, generalized pustular psoriasis (GPP).A cross-sectional descriptiveretrospective study was conducted between January 2014 and June 2023 at the dermatology clinics of

Keywords: Acute Generalized Exanthematous Pustulosis, Adult-onset immunodeficiency, Anti-interferongamma autoantibodies, Pustular psoriasis, Pustular reaction

Received: 29 Apr 2025; Accepted: 06 Aug 2025.

Copyright: © 2025 Julanon, Danpanichkul, Choonhakarn, Chaowattanapanit, Anunnatsiri, Chetchotisakd, Kiratikanon, Rujiwetpongstorn, Tovanabutra, Chiewchanvit, Chaiwarith, Phinyo and Chuamanochan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mati Chuamanochan, Chiang Mai University, Chiang Mai, Thailand

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material