ORIGINAL RESEARCH article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1620027
This article is part of the Research TopicNew Insights into Inflammation Driven Autoimmune Skin Disorders: Trends and ChallengesView all 4 articles
Accelerated biological aging as a potential mediator mediates the relationship between metabolic syndrome and the risk of psoriasis: A prospective analysis from the UK biobank
Provisionally accepted
- 1The First Affiliated Hospital of Jinan University, Guangzhou, China
- 2jinan university, Guangzhou, China
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Background: Increasing evidence suggests that metabolic syndrome (MetS) may contribute to the development of psoriasis. However, the mediating role of accelerated aging in this association remains unclear.Methods: This study utilized data from 319,263 participants in the UK Biobank. Cox proportional hazards models were used to assess the associations between MetS, genetic predisposition, and psoriasis risk. Mediation analysis examined the role of accelerated aging (PhenoAgeAccel) in the relationship between MetS, its components, and psoriasis.Results: MetS was associated with a 30% increased risk of psoriasis (HR: 1.30; 95% CI: 1.20-1.40). Among its components, abdominal obesity, low HDL cholesterol, high triglycerides, and hyperglycemia were each independently linked to higher risk. Individuals with both MetS and high genetic susceptibility had a substantially increased risk (HR: 2.93; 95% CI: 2.51-3.43). PhenoAgeAccel significantly mediated 28.8% of the MetS-psoriasis association.: MetS and its components play a key role in psoriasis development, especially in genetically susceptible individuals. Accelerated aging may partially explain this link, suggesting a potential biological pathway and underscoring the importance of early MetS identification.
Keywords: metabolic syndrome, Psoriasis, Genetic Susceptibility, 50 Biological aging, Mediation analysis
Received: 29 Apr 2025; Accepted: 16 Jul 2025.
Copyright: © 2025 Tian, Qiu, Zhang, Chen, Yu, Lyu, Lau and Deng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Liehua Deng, The First Affiliated Hospital of Jinan University, Guangzhou, China
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